The purpose of this conceptual framework is to further analyze the connection between depression and acculturation among Haitian Americans. There is a limited amount of research conducted on immigrants dealing with depression in relation to acculturating into America. Even less research is conducted on Haitian immigrants. The research method used for this paper will be through the review of the literature. The results showed that the less a Haitian immigrant is able to acculturate the higher their chances of becoming depressed. The paper concludes with what can be done in order to decrease the number of first-generation Haitian Americans with depression in relation to acculturation.